VPCIR™ REEAD (Rolling Circle Enhance Enzyme Activity Detection) product line is focused on measurement of topoisomerase 1 activity.

They are assay kits for measurement of overall topoisomerase 1 activity (VPCIR™ REEAD TOP1 activity) and will also include an assay capable of measuring the cleavage and ligation activity of topoisomerase 1 separately (VPCIR™ REEAD C|L TOP1 activity).

These products may be used with various inputs recombinant type 1B topoisomerases (e.g., human nuclear, human mitochondrial, monkeypox, malaria).

VPCIR™ REEAD are used for:

  • Drug screening for topoisomerase 1 inhibitors in chemotherapy
  • Drug screening for topoisomerase 1 inhibitors for protozoal pathogens
  • Research in certain cancers
  • Research in certain chronic and infectious diseases
  • Tests for malaria (Plasmodium) and other protozoa, and for monkeypox